The impaired motility observed in NCCP patients may play a relevant role in delaying reflux clearing, hence increasing the time of contact between refluxate and esophageal mucosa. was 0.05. patients belonging to Group 1, the majority of reflux episodes associated with chest pain were acid and mixed. The proportion of mixed refluxes was higher than that in Group 2. In Group 1, the reflux clearing time at 5, 9, and 15 cm, measured in reflux episodes associated to NCCP was longer than in reflux episodes associated to common symptoms (imply 95% CI: 27.2 5.6, 23.3 4.4, and 14.6 2.3 seconds vs 18.3 3.5, 13.3 2.2, and 11.1 1.8 seconds; 0.01). Conclusions The presence of gas in the refluxate seems to be associated with NCCP. The impaired motility observed in NCCP patients may play a relevant role in delaying reflux clearing, hence increasing the time of contact between refluxate and esophageal mucosa. was 0.05. The statistical analysis was performed using SPSS 16.0 software (SPSS Inc, Chicago, IL, USA). Results Patients According to the findings from your questionnaire, 41/48 Group 1 patients were classified as having predominant NCCP and concomitant common symptoms occurrence; the remaining 7 patients presented NCCP SNX-5422 Mesylate episodes alone. Demographic characteristics of the 2 2 groups are in Table 1. No differences were found in terms of body mass index, smoking and alcohol consumption. Table 1 Demographic Characteristics of the Groups 1 and 2 0.05). Overall 14 of these 29 Group 1 patients showed ineffective esophageal motility (IEM), 9 fragmented peristalsis and 6 absent contractility. Of the 12 patients belonging to Group 2, seven showed IEM and 5 fragmented peristalsis (Fig. 2). Two patients of Group 1 and 4 of Group 2 showed findings of hypertensive peristalsis. Mean DCI value was significantly lower in Group 1. Mean integrated relaxation pressure, DL, and CFV values were comparable between the 2 groups (Table 2). Open in a separate window Physique 2 High-resolution manometry tracing showing the SNX-5422 Mesylate presence of a large defect of the peristalsis in a noncardiac chest pain patient. UES, upper esophageal sphincter; LES, lower esophageal sphincter. Table 2 Mean ( SD) Integrated Relaxation Pressure, Distal Latency, Contractile Front Velocity, and Distal Contractile Integral Values in Groups 1 and 2 = 0.005. IRP, integrated relaxation pressure; DL, distal latency; CFV, contractile front velocity; DCI, distal contractile integral. Multichannel SNX-5422 Mesylate Intraluminal Impedance-pH Findings Of the 48 patients in Group 1, 22 showed a pathological AET (mean 8.5%, range 5.4C17.1%) and 26 showed a normal pH profile (mean 2.1%, range 0.6C4.2%). Of the 50 patients belonging to Group 2, 24 showed a pathological AET (imply 7.7%, range 5.9C14.8%) and 26 showed a normal pH profile (mean 2.3%, range 0.9C43.9%). The proportion of patients with a pathological AET were similar between Groups 1 and 2 (54% vs 52%, = NS). The reflux frequency and proportions of acid and proximal reflux episodes were comparable between Groups 1 and 2. Patients in Group 1 were characterized by a higher proportion of mixed reflux episodes compared to patients in Group 2 (Table 3). Table 3 Multichannel Intraluminal Impedance-pH Findings in Groups 1 and 2. In Group 1, the Majority of Reflux Episodes Associated with Chest Pain Were Acid and Mixed, Whilst the Majority of Refluxes Associated with Common Symptoms Were Proximal = 0.004. Symptom-reflux Association Analysis A total of 302 NCCP episodes and 285 common symptom episodes associated with refluxes (9.1% of all reflux events, range 3.8C12.7% and 10.2%, range 3.9C14.1%, respectively) were reported in Groups 1 and 2 during the 24 hours. The per patients frequency Rabbit polyclonal to PDK4 of NCCP-associated reflux episodes was comparable to that of common symptom-associated reflux episodes (mean SD, 5.9 2.7 and 5.7 2.8). During the MII-pH monitoring, 41 out of 48 patients with NCCP also reported 126 common symptoms associated to reflux episodes (imply SD, 3.1 1.1). Characteristics of symptomatic and asymptomatic reflux episodes in both groups are pointed out in Table 4. In Group 1, the majority of reflux episodes associated with chest pain were acid and mixed, whilst the majority of refluxes associated with common symptoms were proximal. The proportion of mixed refluxes associated with NCCP was higher than the proportion of mixed refluxes associated with SNX-5422 Mesylate common symptoms, both in Groups 1 and 2. In the multivariate model, SNX-5422 Mesylate in Group 1, a mixed reflux episode was most probably perceived as.
